Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for α-synuclein fibrils in vitro
作者： Mie Hirohata , Kenjiro Ono , Akiyoshi Morinaga , Masahito Yamada
DOI: 10.1016/J.NEUROPHARM.2007.11.010
关键词:
摘要: The aggregation of alpha-synuclein (alphaS) in the brain has been implicated as a critical step development Lewy body diseases (LBD) [Parkinson's disease (PD)/dementia with bodies (DLB)] and multiple system atrophy (MSA). involvement neuroinflammation microglial activation emphasized pathogenesis PD. Recent epidemiological studies have revealed that therapeutic use non-steroidal anti-inflammatory drugs (NSAIDs) reduces risk developing Here, we examined effects NSAIDs, such ibuprofen, aspirin, acetaminophen, meclofenamic acid sodium salt, sulindac sulfide, ketoprofen, flurbiprofen, diclofenac naproxen, indomethacin, on formation destabilization alphaS fibrils (falphaS) at pH 7.5 37 degrees C vitro, using fluorescence spectroscopy thioflavin S electron microscopy. All except for naproxen inhibited falphaS dose-dependent manner. Moreover, these molecules dose-dependently destabilized preformed falphaS. overall activity was order: ibuprofen approximately aspirin acetaminophen salt sulfide>ketoprofen flurbiprofen salt>naproxen indomethacin. These findings indicate NSAIDs could be key or preventive agents LBD MSA.
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sci-hub.se 参考文章(40)
Masato Asanuma, Sakiko Nishibayashi-Asanuma, Ikuko Miyazaki, Masahiro Kohno, Norio Ogawa, Neuroprotective effects of non‐steroidal anti‐inflammatory drugs by direct scavenging of nitric oxide radicals Journal of Neurochemistry. ,vol. 76, pp. 1895- 1904 ,(2001) , 10.1046/J.1471-4159.2001.00205.X
Masami Masuda, Nobuyuki Suzuki, Sayuri Taniguchi, Takayuki Oikawa, Takashi Nonaka, Takeshi Iwatsubo, Shin-ichi Hisanaga, Michel Goedert, Masato Hasegawa, Small Molecule Inhibitors of α-Synuclein Filament Assembly† Biochemistry. ,vol. 45, pp. 6085- 6094 ,(2006) , 10.1021/BI0600749
Qiao Yan, Jianhua Zhang, Hantao Liu, Safura Babu-Khan, Robert Vassar, Anja Leona Biere, Martin Citron, Gary Landreth, Anti-Inflammatory Drug Therapy Alters β-Amyloid Processing and Deposition in an Animal Model of Alzheimer's Disease The Journal of Neuroscience. ,vol. 23, pp. 7504- 7509 ,(2003) , 10.1523/JNEUROSCI.23-20-07504.2003
Michel Goedert, Alpha-synuclein and neurodegenerative diseases. Nature Reviews Neuroscience. ,vol. 2, pp. 492- 501 ,(2001) , 10.1038/35081564
Mel B. Feany, Welcome W. Bender, A Drosophila model of Parkinson's disease Nature. ,vol. 404, pp. 394- 398 ,(2000) , 10.1038/35006074
Ikuru Yazawa, Benoit I. Giasson, Ryogen Sasaki, Bin Zhang, Sonali Joyce, Kunihiro Uryu, John Q. Trojanowski, Virginia M.-Y. Lee, Mouse Model of Multiple System Atrophy α-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration Neuron. ,vol. 45, pp. 847- 859 ,(2005) , 10.1016/J.NEURON.2005.01.032
M. K. Lee, W. Stirling, Y. Xu, X. Xu, D. Qui, A. S. Mandir, T. M. Dawson, N. G. Copeland, N. A. Jenkins, D. L. Price, Human α-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with α-synuclein aggregation in transgenic mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 8968- 8973 ,(2002) , 10.1073/PNAS.132197599
M. Grilli, M. Pizzi, M. Memo, P. Spano, Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation Science. ,vol. 274, pp. 1383- 1385 ,(1996) , 10.1126/SCIENCE.274.5291.1383
H. Maharaj, D.S. Maharaj, S. Daya, Acetylsalicylic acid and acetaminophen protect against MPP+-induced mitochondrial damage and superoxide anion generation. Life Sciences. ,vol. 78, pp. 2438- 2443 ,(2006) , 10.1016/J.LFS.2005.10.002
Kenjiro Ono, Mie Hirohata, Masahito Yamada, Anti‐fibrillogenic and fibril‐destabilizing activities of anti‐Parkinsonian agents for α‐synuclein fibrils in vitro Journal of Neuroscience Research. ,vol. 85, pp. 1547- 1557 ,(2007) , 10.1002/JNR.21271