Inhibition of glutathione reductase by flavonoids: A structure-activity study
作者： Andrew J. Elliott , Sandra A. Scheiber , Carin Thomas , Ronald S. Pardini
DOI: 10.1016/0006-2952(92)90478-2
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摘要: A structure-activity study of fourteen chemically related flavonoids was conducted to evaluate their abilities to inhibit glutathione reductase (GR). By comparing the I 50 values of flavonoids from different classes possessing an identical hydroxyl configuration, we determined the following order of potency for inhibition of GR: anthocyanidin> dihydroflavonol= chalcone> flavonol> catechin. Enzyme inhibition by delphinidin chloride and myricetin was partially prevented in a N 2 atmosphere which implicates a role for …
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