Hormone replacement: therapeutic strategies in the treatment of Alzheimer’s disease and ageing-related cognitive disorders
作者： Farida Sohrabji , Rajesh C Miranda
关键词:
摘要: While the incidence of cognitive disorders such as Alzheimer’s disease (AD) is increasing among ageing populations Europe and North America, few therapeutic agents have been identified for effective management. Substantial recent evidence suggests that neurological circuits targeted by AD are also sensitive to gonadal hormones oestrogen. This review examines hormone replacement therapy a possible strategy management ageing-related disorders, emphasising cellular/molecular actions We examine patent literature promising trends in hormone-related therapeutics, especially advances related development tissue-selective oestrogenic compounds. combining oestrogen with other compounds increase their efficacy.
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