Mechanisms of immunity to malaria and the possibilities of a blood-stage vaccine: a critical appraisal.
作者： G. A. Butcher
DOI: 10.1017/S0031182000062247
关键词:
摘要: Resistance developed by the immune system in response to blood-stage malaria is complex nature, involving humoral and non-antibody effector mechanisms. Different species of malarial parasites may vary their ability elicit, or susceptibility to, those effectors. This complexity enhanced different results obtained vaccinated as opposed drug-controlled infections. It therefore important that some attempt be made unravel these interactions. particularly so when we have decide on methods for assessing potentiality antigens induce protective immunity. In this review limitations vitro assays immunity, well various host-parasite models, are discussed. The relative importance cell-mediated immunity laboratory models natural infections also considered context vaccine development.
sci-hub.se 参考文章(117)
S. Cohen, G. A. Butcher, G. H. Mitchell, Immunization Against Erythrocytic Forms of Malaria Parasites Advances in Experimental Medicine and Biology. ,vol. 93, pp. 89- 112 ,(1977) , 10.1007/978-1-4615-8855-9_7
Janice Taverne, Jan Tavernier, Walter Fiers, Jhl Playfair, Recombinant tumour necrosis factor inhibits malaria parasites in vivo but not in vitro. Clinical and Experimental Immunology. ,vol. 67, pp. 1- 4 ,(1987)
S. Cohen, G. A. Butcher, Antigenic variation and protective immunity in Plasmodium knowlesi malaria. Immunology. ,vol. 23, pp. 503- ,(1972)
S Cohen, G H Mitchell, G A Butcher, Antibody mediated mechanisms of immunity to malaria induced by vaccination with Plasmodium knowlesi merozoites. Immunology. ,vol. 34, pp. 77- 86 ,(1978)
R R Freeman, A A Holder, Characteristics of the protective response of BALB/c mice immunized with a purified Plasmodium yoelii schizont antigen. Clinical and Experimental Immunology. ,vol. 54, pp. 609- 616 ,(1983)
S Jepsen, A Kharazmi, Enhanced inhibition of in vitro multiplication of Plasmodium falciparum by stimulated human polymorphonuclear leucocytes. Clinical and Experimental Immunology. ,vol. 57, pp. 287- 292 ,(1984)
L H Miller, D E Hudson, F W Klotz, P H David, T J Hadley, Immunization of monkeys with a 140 kilodalton merozoite surface protein of Plasmodium knowlesi malaria: appearance of alternate forms of this protein. Journal of Immunology. ,vol. 134, pp. 4146- 4152 ,(1985)
R.S. Phillips, R.A. Wolstencroft, I.N. Brown, K.N. Brown, D.C. Dumonde, Immunity to malaria Experimental Parasitology. ,vol. 28, pp. 339- 355 ,(1970) , 10.1016/0014-4894(70)90103-7
H Wigzell, R Shabo, G V Alm, O A Akinwolere, E A Ojo-Amaize, A I Williams, L S Salimonu, Positive correlation between degree of parasitemia, interferon titers, and natural killer cell activity in Plasmodium falciparum-infected children. Journal of Immunology. ,vol. 127, pp. 2296- 2300 ,(1981)
N H Hunt, I A Clark, W B Cowden, G A Butcher, Inhibition of murine malaria (Plasmodium chabaudi) in vivo by recombinant interferon-gamma or tumor necrosis factor, and its enhancement by butylated hydroxyanisole. Journal of Immunology. ,vol. 139, pp. 3493- 3496 ,(1987)