Effect of adriamycin on the cell cycle traverse and kinetics of cultured human lymphoblasts.

摘要: Exposure of cultured human lymphoblasts to adriamycin (ADM) (0.1 μg/ml for 24 hr or 0.5 1 hr) leads an accumulation cells with the DNA content late S and G2. Higher concentrations ADM (0.5 10 μg/ml) inhibit cell cycle traverse. Effect on traverse, growth, incorporation labeled precursors into is dependent drug concentration length exposure ADM. Synchronized in G1 G2 part are less sensitive than phase. Similarly, plateau-phase from log-phase cultures.