Baclofen novel gastroretentive extended release gellan gum superporous hydrogel hybrid system: in vitro and in vivo evaluation

摘要: Baclofen is a centrally acting skeletal muscle relaxant with short elimination half-life, which results in frequent daily dosing and subsequent poor patient compliance. The narrow absorption window of baclofen the upper gastrointestinal tract limits its formulation as extended release dosage forms. In this study, superporous hydrogel (SPH) systems, including conventional SPH, SPH composite hybrid (SPHH), were prepared aiming to increase residence at window. applicability different polymers, namely, gellan gum, guar polyvinyl alcohol gelatin, was investigated preparation SPHH systems. systems evaluated regarding weight volume swelling ratio, porosity, mechanical properties, incorporation efficiency, degree erosion drug release. vivo assessment performed dogs evaluate gastric time by X-ray studies. addition, oral bioavailability relative commercially available Lioresal® immediate tablets also investigated. novel cross linked calcium chloride characterized optimum acceptable properties well It exhibited prolonged plasma profile when compared twice administered Lioresal®.