A novel protocol for solvent-free synthesis of 4,6-diaryl-3,4-dihydropyrimidine-2(1H)-ones catalyzed by metal oxide–MWCNTs nanocomposites

摘要: A Biginelli-like condensation is described using acetophenone as active methylene compound with aldehydes and urea to furnish pyrimidinone analogues under solvent-free conditions. In this paper, besides the preparation of nanocomposites based on MWCNTs, our investigations have been focused catalytic efficiency metal oxide–MWCNTs composites. The requisites a good catalyst are high activity, selectivity, reusability, reasonable cost long lifetime. application conditions transition oxides decorated–MWCNTs (MOx–MWCNTs) attractive, effective reusable catalysts leads efficient synthesis 4,6-diaryl-3,4-dihydropyrimidin-2-(1H)-ones. This recyclable heterogeneous system provides simple strategy generate variety pyrimidinones Utilization easy reaction condition, green catalyst, reduced environmental impacts work-up make methodology an interesting option for eco-friendly compounds.