Stereotactic Radiosurgery as the Initial Treatment for Patients with Nonfunctioning Pituitary Adenomas

摘要: Objective The aim of this study was to confirm the efficacy and safety stereotactic radiosurgery as initial treatment for patients with nonfunctioning pituitary adenomas (NFPAs) decide optimum dose achieve long-term tumor control well preservation endocrine function. Methods a single-center retrospective analysis 16 primary NFPAs that were treated gamma knife surgery (GKS). Fifteen growing suprasellar region slightly compressing or very close optic apparatus. Initial GKS selected avoid visual disturbance caused by further growth would require surgical resection under general anesthesia. median volume 2.0 cm 3 , margin 15 Gy. Results clinical follow-up period 98 months. last images demonstrated regression in stable 1. No patient developed progression. One who had apoplexy before required hormone replacements 2 years after GKS. other did not experience insufficiency requiring hormone–replacement therapy during period. cranial nerve injury radiation-induced neoplasm. Conclusions is safe effective option NFPAs, especially advanced age comorbidity. Attention should be paid late adverse radiation effects such hypopituitarism, neuropathy, neoplasms. However, conformal plan sparing normal gland will contribute avoidance complications achievement control.