Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway.

作者: M. Ueno , J. B. C. Carvalheira , R. C. Tambascia , R. M. N. Bezerra , M. E. Amaral

DOI: 10.1007/S00125-004-1662-6

关键词:

摘要: Aim/hypothesis Several epidemiological studies have suggested an association between chronic hyperinsulinaemia and insulin resistance. However, the causality of this relationship remains uncertain.

参考文章(41)
M.G. Myers, T.C. Grammer, L.M. Wang, X.J. Sun, J.H. Pierce, J Blenis, M.F. White, Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. Journal of Biological Chemistry. ,vol. 269, pp. 28783- 28789 ,(1994) , 10.1016/S0021-9258(19)61974-5
J.F. Tanti, T. Grémeaux, E. van Obberghen, Y. Le Marchand-Brustel, Serine/threonine phosphorylation of insulin receptor substrate 1 modulates insulin receptor signaling. Journal of Biological Chemistry. ,vol. 269, pp. 6051- 6057 ,(1994) , 10.1016/S0021-9258(17)37568-3
Pi-Yun Chang, Yannick Le Marchand-Brustel, Lynn A. Cheatham, David E. Moller, Insulin Stimulation of Mitogen-activated Protein Kinase, p90rsk, and p70 S6 Kinase in Skeletal Muscle of Normal and Insulin-resistant Mice IMPLICATIONS FOR THE REGULATION OF GLYCOGEN SYNTHASE Journal of Biological Chemistry. ,vol. 270, pp. 29928- 29935 ,(1995) , 10.1074/JBC.270.50.29928
Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery, Deborah J. Burks, Jian-Ming Ren, Stephen Previs, Yitao Zhang, Dolores Bernal, Sebastian Pons, Gerald I. Shulman, Susan Bonner-Weir, Morris F. White, Disruption of IRS-2 causes type 2 diabetes in mice Nature. ,vol. 391, pp. 900- 904 ,(1998) , 10.1038/36116
S Lo, J C Russell, A W Taylor, Determination of glycogen in small tissue samples. Journal of Applied Physiology. ,vol. 28, pp. 234- 236 ,(1970) , 10.1152/JAPPL.1970.28.2.234
S. Krief, R. Bazin, F. Dupuy, M. Lavau, Increased in vivo glucose utilization in 30-day-old obese Zucker rat: role of white adipose tissue. American Journal of Physiology-endocrinology and Metabolism. ,vol. 254, ,(1988) , 10.1152/AJPENDO.1988.254.3.E342
I Cusin, J Terrettaz, F Rohner-Jeanrenaud, B Jeanrenaud, Metabolic consequences of hyperinsulinaemia imposed on normal rats on glucose handling by white adipose tissue, muscles and liver Biochemical Journal. ,vol. 267, pp. 99- 103 ,(1990) , 10.1042/BJ2670099
M J Saad, F Folli, J A Kahn, C R Kahn, Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. Journal of Clinical Investigation. ,vol. 92, pp. 2065- 2072 ,(1993) , 10.1172/JCI116803
Gökhan S Hotamisligil, Pascal Peraldi, Adriane Budavari, Ramsey Ellis, Morris F White, Bruce M Spiegelman, IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance Science. ,vol. 271, pp. 665- 668 ,(1996) , 10.1126/SCIENCE.271.5249.665