3 Mutational analyses of protein farnesyltransferase
作者： Jun Urano , Wenli Yang , Fuyuhiko Tamanoi
DOI: 10.1016/S1874-6047(01)80016-0
关键词:
摘要: Publisher Summary This chapter discusses deletion studies that defined the minimal size of farnesyltransferase (FTase) subunits critical for structural integrity and function enzyme. The describes identification characterization a variety FTase mutants exhibit altered zinc binding, substrate affinity, catalysis. also different approaches led to possessing specificity. Some obtained by mutational analyses may provide valuable tools with which evaluate physiological FTase. For example, resistant inhibitor (FTI) could be used determine whether any biological effects FTI are indeed because inhibition Both mammalian yeast discussed in chapter, as there striking similarities behavior enzymes carrying analogous mutations.
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