Massive Parallel Catalyst Screening: Toward Asymmetric MCRs
作者： Ulrike Kusebauch , Barbara Beck , Kim Messer , Eberhardt Herdtweck , Alexander Dömling
DOI: 10.1021/OL035010U
关键词:
摘要: [reaction: see text]. Hundreds of Lewis acid/ligand combinations have been screened for stereochemical induction in the Passerini multicomponent reaction. The combination titan tetraisopropylate and (4S,5S)-4,5-bis(diphenylhydroxymethyl)-2,2-dimethyldioxolane was found to give enantiomeric excesses between 32% 42% several examples. absolute stereo one example determined chemically by means X-ray crystallography. This comprises first asymmetric reaction a an isocyanide based chiral acid.
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