Protection Against Carbon Tetrachloride-Induced Lipid Peroxidation in the Rat by Dietary Vitamin E, Selenium, and Methionine as Measured by Ethane Evolution

摘要: Dietary vitamin E, selenium (Se), and methionine were tested for their ability to inhibit carbon tetrachloride (CCL4)-induced lipid peroxidation. Peroxidation, in vivo, was monitored by the evolution of ethane, an autoxidation product omega-3-unsaturated fatty acids. Weanling rats fed a basal diet low Se, sulfur-containing amino acids, or diets individually supplemented with these factors. After 3 7 weeks, injected CCL4 (ip) ethane collected 9 hours. Cumulative increased CCl4 all groups. Vitamin reduced from CCl4-treated 82%, 74%, 60%, respectively. The toxicity decreased correlation evolution. Thus, probably maintaining intracellular glutathione peroxidase, protected against CCl4-induced peroxidation, as did E. Substitution cod liver oil, which is rich fat, lard six-fold. Relative inhibition dietary supplements not changed. feeding oil greatly production facilitated detection measurement peroxidation vivo.