Esmolol promotes electroencephalographic burst suppression during propofol/alfentanil anesthesia.
作者： Jay W. Johansen
DOI: 10.1097/00000539-200112000-00039
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摘要: This study examined the effects of an esmolol infusion on electroencephalogram during propofol/alfentanil IV anesthesia. After informed consent, 20 patients were randomly assigned into four groups basis two target alfentanil concentrations (alfentanil 50 or 150 ng/mL) and a saline infusion. Bispectral index (BIS), burst suppression ratio (SR), physiologic variables continuously monitored. A 30-min blinded was started after establishing stable baseline followed by washout period. The significantly suppressed (BIS, 37 6t o 22 6, 40% decrease [mean sd]; SR, 5 7 to 67 23, 13.4-fold increase) compared with in small-dose groups. Discontinuation reversed response. BIS SR unaffected placebo Twelve-minute 16-min hysteresis between administration onset halfmaximal cortical observed. Physiologic serum propofol not altered esmolol. Although mechanism remains unclear, significant depression stable, computer-controlled anesthetic associated
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sci-hub.se 参考文章(25)
RALF HEMMINGSEN, MARIANNE M. HERTZ, DAVID I. BARRY, The effect of propranolol on cerebral oxygen consumption and blood flow in the rat: measurements during normocapnia and hypercapnia Acta Physiologica Scandinavica. ,vol. 105, pp. 274- 281 ,(1979) , 10.1111/J.1748-1716.1979.TB06342.X
Jay W. Johansen, Ronald Flaishon, Peter S. Sebel, Esmolol Reduces Anesthetic Requirement for Skin Incision during Propofol/Nitrous Oxide/Morphine Anesthesia Anesthesiology. ,vol. 86, pp. 364- 371 ,(1997) , 10.1097/00000542-199702000-00011
Oak Za Chi, Xia Liu, Harvey R. Weiss, The effects of propranolol on heterogeneity of rat cerebral small vein oxygen saturation. Anesthesia & Analgesia. ,vol. 89, pp. 690- 695 ,(1999) , 10.1097/00000539-199909000-00030
Check Y Sum, Avraham Yacobi, Ronald Kartzinel, Herman Stampfli, Charles S Davis, Chii-Ming Lai, Kinetics of esmolol, an ultra-short-acting beta blocker, and of its major metabolite. Clinical Pharmacology & Therapeutics. ,vol. 34, pp. 427- 434 ,(1983) , 10.1038/CLPT.1983.193
A. VANDESTEENE, V. TREMPONT, E. ENGELMAN, T. DELOOF, M. FOCROUL, A. SCHOUTENS, M. ROOD, Effect of propofol on cerebral blood flow and metabolism in man Anaesthesia. ,vol. 43, pp. 42- 43 ,(1988) , 10.1111/J.1365-2044.1988.TB09067.X
Eugene Ornstein, William L. Young, Noeleen Ostapkovich, Richard S. Matteo, Jaime Diaz, Are all effects of esmolol equally rapid in onset Anesthesia & Analgesia. ,vol. 81, pp. 297- 300 ,(1995) , 10.1097/00000539-199508000-00015
Jay W. Johansen, Gerhard Schneider, Alastair M. Windsor, Peter S. Sebel, Esmolol potentiates reduction of minimum alveolar isoflurane concentration by alfentanil. Anesthesia & Analgesia. ,vol. 87, pp. 671- 676 ,(1998) , 10.1097/00000539-199809000-00034
B.S Zaret, Prognostic and neurophysiological implications of concurrent burst suppression and alpha patterns in the EEG of post-anoxic coma. Electroencephalography and Clinical Neurophysiology. ,vol. 61, pp. 199- 209 ,(1985) , 10.1016/0013-4694(85)91085-5
L. Herregods, G. Rolly, E. Mortier, M. Bogaert, C. Mergaert, EEG and SEMG monitoring during induction and maintenance of anesthesia with propofol. Journal of Clinical Monitoring and Computing. ,vol. 6, pp. 67- 73 ,(1989) , 10.1007/BF01720415
Donald R. Miller, Raymond J. Martineau, J. E. Wynands, Jeremy Hill, Bolus administration of esmolol for controlling the haemodynamic response to tracheal intubation: the Canadian Multicentre Trial. Canadian Journal of Anaesthesia-journal Canadien D Anesthesie. ,vol. 38, pp. 849- 858 ,(1991) , 10.1007/BF03036959