Comparison of Computed Tomography Perfusion and Magnetic Resonance Imaging Perfusion-Diffusion Mismatch in Ischemic Stroke
作者： Bruce C.V. Campbell , Søren Christensen , Christopher R. Levi , Patricia M. Desmond , Geoffrey A. Donnan
DOI: 10.1161/STROKEAHA.112.660548
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摘要: Background and Purpose—Perfusion imaging has the potential to select patients most likely respond thrombolysis. We tested correspondence of computed tomography perfusion (CTP)-derived mismatch with contemporaneous perfusion-diffusion magnetic resonance (MRI). Methods—Acute ischemic stroke 3 6 hours after onset had CTP MRI within 1 hour, before Relative cerebral blood flow (relCBF) time peak deconvolved tissue residue function (Tmax) were calculated. The diffusion lesion (diffusion-weighted imaging) was registered slabs manually outlined its maximal visual extent. Volumetric accuracy CT-relCBF infarct core (compared diffusion-weighted tested. To reduce false-positive low CBF regions, relCBF restricted voxels a relative time-to-peak (relTTP) >4 seconds for region interest. MR-Tmax >6 automatically segmented CT...
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