Methods for therapy of neurodegenerative disease of the brain
作者： Mark H. Tuszynski
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摘要: A specific clinical protocol for use toward therapy of defective, diseased and damaged cholinergic neurons in the mammalian brain, particular usefulness treatment neurodegenerative conditions such as Alzheimer's disease. The is practiced by delivering a definite concentration recombinant neurotrophin into, or within close proximity of, identified brain cells. Using viral vector, delivered part neurotrophic composition varies from 10?10 to 1015? encoding particles/ml fluid. Each delivery site receives form 2.5 νl 25 composition, slowly, over period time ranging upwards 10 minutes/delivery site. at, 500 νm targeted cell, no more than about mm another Stable situ expression can be achieved 12 months, longer.
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