Melanoma: Advances in Targeted Therapy and Molecular Markers.

Bianca Devitt, Wendy Liu, Renato Salemi, Rory Wolfe, John Kelly, Chin-Yuan Tzen, Alexander Dobrovic, Grant McArthur, Clinical outcome and pathological features associated with NRAS mutation in cutaneous melanoma Pigment Cell & Melanoma Research. ,vol. 24, pp. 666- 672 ,(2011) , 10.1111/J.1755-148X.2011.00873.X

Amanda D. Bucheit, Erica Syklawer, John A. Jakob, Roland L. Bassett, Jonathan L. Curry, Jeffrey E. Gershenwald, Kevin B. Kim, Patrick Hwu, Alexander J. Lazar, Michael A. Davies, Clinical characteristics and outcomes with specific BRAF and NRAS mutations in patients with metastatic melanoma. Cancer. ,vol. 119, pp. 3821- 3829 ,(2013) , 10.1002/CNCR.28306

Jeffrey Alan Sosman, Muaiad Kittaneh, Martijn PJK Lolkema, Michael Andrew Postow, Gary Schwartz, Catherine Franklin, Alessandro Matano, Suraj Bhansali, Sudha Parasuraman, Kevin Kim, None, A phase 1b/2 study of LEE011 in combination with binimetinib (MEK162) in patients with NRAS-mutant melanoma: Early encouraging clinical activity. Journal of Clinical Oncology. ,vol. 32, pp. 9009- 9009 ,(2014) , 10.1200/JCO.2014.32.15_SUPPL.9009

Genevieve M. Boland, Funda Meric-Bernstam, The role of surgeons in building a personalized medicine program Journal of Surgical Oncology. ,vol. 111, pp. 3- 8 ,(2015) , 10.1002/JSO.23684

Thomas K. Hoffmann, Eniko Sonkoly, Ulrich Hauser, Anke van Lierop, Theresa L. Whiteside, Jens Peter Klussmann, Dieter Hafner, Patrick Schuler, Ulrike Friebe-Hoffmann, Kathrin Scheckenbach, Kaisa Erjala, Reidar Grénman, Jörg Schipper, Henning Bier, Vera Balz, Alterations in the p53 pathway and their association with radio- and chemosensitivity in head and neck squamous cell carcinoma. Oral Oncology. ,vol. 44, pp. 1100- 1109 ,(2008) , 10.1016/J.ORALONCOLOGY.2008.02.006

Irene Sánchez-Hernández, Pablo Baquero, Laura Calleros, Antonio Chiloeches, Dual inhibition of V600EBRAF and the PI3K/AKT/mTOR pathway cooperates to induce apoptosis in melanoma cells through a MEK-independent mechanism Cancer Letters. ,vol. 314, pp. 244- 255 ,(2012) , 10.1016/J.CANLET.2011.09.037

Caroline Robert, Boguslawa Karaszewska, Jacob Schachter, Piotr Rutkowski, Andrzej Mackiewicz, Daniil Stroiakovski, Michael Lichinitser, Reinhard Dummer, Florent Grange, Laurent Mortier, Vanna Chiarion-Sileni, Kamil Drucis, Ivana Krajsova, Axel Hauschild, Paul Lorigan, Pascal Wolter, Georgina V Long, Keith Flaherty, Paul Nathan, Antoni Ribas, Anne-Marie Martin, Peng Sun, Wendy Crist, Jeff Legos, Stephen D Rubin, Shonda M Little, Dirk Schadendorf, None, Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib The New England Journal of Medicine. ,vol. 372, pp. 30- 39 ,(2015) , 10.1056/NEJMOA1412690

Samantha Robinson, Sandra Dixon, Suzannah August, Brian Diffey, Kazumasa Wakamatsu, Shosuke Ito, Peter S. Friedmann, Eugene Healy, Protection against UVR Involves MC1R-Mediated Non-Pigmentary and Pigmentary Mechanisms In Vivo Journal of Investigative Dermatology. ,vol. 130, pp. 1904- 1913 ,(2010) , 10.1038/JID.2010.48

Alexander M. Menzies, Georgina V. Long, Recent advances in melanoma systemic therapy. BRAF inhibitors, CTLA4 antibodies and beyond European Journal of Cancer. ,vol. 49, pp. 3229- 3241 ,(2013) , 10.1016/J.EJCA.2013.06.027

Lawrence N Kwong, James C Costello, Huiyun Liu, Shan Jiang, Timothy L Helms, Aliete E Langsdorf, David Jakubosky, Giannicola Genovese, Florian L Muller, Joseph H Jeong, Ryan P Bender, Gerald C Chu, Keith T Flaherty, Jennifer A Wargo, James J Collins, Lynda Chin, Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma Nature Medicine. ,vol. 18, pp. 1503- 1510 ,(2012) , 10.1038/NM.2941