A residence-time distribution analysis of the hydrodynamics within the intestine in man during a regional single-pass perfusion with Loc-I-Gut: in-vivo permeability estimation.
作者： HANS LENNERNÄS , I-DER LEE , URBAN FAGERHOLM , GORDON L. AMIDON
DOI: 10.1111/J.2042-7158.1997.TB06092.X
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摘要: The goal of this study was to determine the most appropriate hydrodynamic model for Loc-I-Gut in-vivo perfusion system. general mixing-tank-in-series model, which can approximate single mixing tank and laminar plug-flow hydrodynamics, fitted observed experimental residence-time distribution curves non-absorbable marker [14C]PEG 4000. analysis shows that hydrodynamics solution within jejunal segment in man is well approximately by a containing on average between 1-2 tanks series. mixed when using rates 2.0, 3.0 6.0 mL min-1. mean residence time estimates from were 12 +/- 7.6, 15 4.2 7.7 4.6 min, respectively, at these three rates. volumes (Vs) 25 15, 45 46 27 mL, respectively. There no statistical differences min-1 respect number (n) times. This indicates luminal fluid system well-mixed, permeability calculations based well-mixed assumption closely actual local (average) membrane perfused segment.
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