Neuroproteomics of the Synapse: Subcellular Quantification of Protein Networks and Signaling Dynamics.

摘要: One of the most fascinating features brain is its ability to adapt surroundings. Synaptic plasticity, dynamic mechanism functional and structural alterations in synaptic strength, essential for functioning underlies a variety processes such as learning memory. While molecular mechanisms underlying rapid plasticity are not fully understood, consensus exists on important role proteins. The study these neuronal proteins using neuroproteomics has increased rapidly last decades, advancements mass spectrometry-based proteomics have broadened our understanding neuroplasticity exponentially. In this review, we discuss trends protein-protein interactions protein signaling dynamics, with focus sample types, different labeling enrichment approaches data analysis interpretation. We highlight studies from five years, synapse structure, composition, functioning, or signaling, finally some recent developments that could further advance field neuroproteomics.