The privilege of expressing CD44v - used by immune cells, misused by tumour cells
作者： J. Moll , M. Plug , H. Ponta , P. Herrlich
DOI: 10.1007/978-3-642-61122-3_27
关键词:
摘要: Transgenic mice were generated which express CD44v4-v7 on the surface of 20-80% their T cells, depending lymphoid organ cells derived from. Soluble CD44(v4-v7) is present in serum, showing that, like CD44s, CD44v can be shedded from cell surface. The incidence chemically induced lymphomas these animals was not increased as compared to control mice, nor tumours more aggressive. importance malignancies and during early stages hemopoietic differentiation are discussed.
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