Iron acquisition systems in the pathogenic Neisseria.

摘要: Pathogenic neisseriae have a repertoire of high-affinity iron uptake systems to facilitate acquisition this essential element in the human host. They possess surface receptor proteins that directly bind extracellular host iron-binding transferrin and lactoferrin. Alternatively, they siderophore receptors capable scavenging when exogenous siderophores are present. Released intracellular haem present form haemoglobin, haemoglobin-haptoglobin or free can be used as source for growth through direct binding by specific receptors. Although these may vary complexity composition, key protein involved transport (as iron, iron-siderophore) across outer membrane is TonB-dependent with an overall structure presumably similar determined recently Escherichia coli FhuA FepA. The potentially ideal vaccine targets view their critical role survival Preliminary pilot studies indicate receptor-based vaccines protective humans.