Immunomodulation of inflammatory conditions utilizing Follistatin-like Protein-1 and agents that bind thereto

摘要: Follistatin-like protein (FSTL-1) is a secreted glycoprotein of unknown function, first isolated from mouse osteoblastic cells as transforming growth factor-β1-inducible gene. The inventors have discovered that FSTL-1 proinflammatory mediator. As such, the invention provides for composition and methods using agents bind to modulate various types inflammation (e.g., autoimmune diseases). Inhibitors antagonists FSTL-1, particularly antibodies or antibody fragments, may be used treat conditions related inflammation, such arthritis. In addition, has role in Th17 pathway. Accordingly, compositions which generation cells. Such are useful delaying development treating diseases associated with undesired production cells, diseases. Furthermore, since mediator cancer, pharmaceutical delay cancer.