Acid–base balance during hypoxic hypometabolism: selected vertebrate strategies

摘要: Abstract An important functional advantage of hypoxic hypometabolism is that it blunts the acid–base consequences hypoxia. Hypoxia can lead to anaerobiosis and metabolic acidosis and, in animals are apneic, respiratory acidosis. A fall blood tissue pH a major limiting factor tolerance variety strategies occur vertebrates, concert with hypometabolism, respond this challenge. These include sequestering lactic acid away from circulating during exposure, either underperfused tissues or mineralized tissues, supplementing extracellular buffering by releasing bone mineral into circulation, utilizing alternative pathways for produce ethanol rather than lactate as principal end-product. For submerged air-breathing ectotherms, effective cutaneous O 2 CO exchange also allow an animal avoid minimize both responses serve maintain viable state body extend time stress be endured.