Increased frequency of genetic thrombophilia in women with complications of pregnancy.
作者： Michael J. Kupferminc , Amiram Eldor , Nitzan Steinman , Ariel Many , Amiram Bar-Am
DOI: 10.1056/NEJM199901073400102
关键词:
摘要: Background Obstetrical complications such as severe preeclampsia, abruptio placentae, fetal growth retardation, and stillbirth are associated with intervillous or spiral-artery thrombosis inadequate placental perfusion. Whether these an increased frequency of thrombophilic mutations is not known. Methods We studied 110 women who had one the above-mentioned obstetrical more normal pregnancies. The were tested several days after delivery for mutation adenine to guanine at nucleotide 506 in factor V gene (factor Leiden), cytosine thymine 677 encoding methylenetetrahydrofolate reductase, 20210 prothrombin gene. Two three months deficiency protein C, S, antithrombin III presence anticardiolipin antibodies. Results nucl...
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