Pyrrole and pyrazole daao inhibitors
作者： Michele Heffernan , Milan Chytil , Q. Kevin Fang , Seth Hopkins
DOI:
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摘要: Methods for increasing D-Serine concentration and reducing of the toxic products oxidation, enhancing learning, memory and/or cognition, or treating schizophrenia, Alzheimer's disease, ataxia neuropathic pain, preventing loss in neuronal function characteristic neurodegenerative diseases involve administering to a subject need treatment therapeutically effective amount compound formula (I), pharmaceutically acceptable salt solvate thereof: (I) wherein R1 R2 are independently selected from hydrogen, halo, nitro, alkyl, acyl, alkylaryl, XYR5; R2, taken together, form 5, 6, 7 8-membered substituted unsubstituted carbocyclic heterocyclic group; X Y O, S, NH, (CR6R7)n; R3 is alkyl M+; M aluminum, calcium, lithium, magnesium, potassium , sodium zinc ion mixture thereof; Z N CR4; R4 R5 aryl, heteroaryl heteroaryl; R6 R7 hydrogen alkyl; n an integer 1 6; at least one R1, other than hydrogen; (CR6R7)n. D-serine cycloserine may be coadministered along with (I).
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