Tracer Kinetic Modeling: Methodology and Applications

摘要: Positron emission tomography (PET) is a medical imaging technique based on the simultaneous detection of pairs 511-keV gamma radiations emitted by annihilation positrons within subject following administration radiotracer. The radiotracer could be any pharmacological molecule or natural molecule, such as water (H2 15O) carbon monoxide (11CO, C15O), where an atom group atoms are replaced with positron emitting isotope. These two particularities (i.e., radiation and labeling) provide functionality versatility PET. In addition, use PET to measure noninvasively biochemical physiological reactions in tissue function time greatly contributes new avenue medicine. has picomolar sensitivity can acquire images frames 10 s humans almost 3 small animals, providing dynamic insights living tissues. Moreover, since imaged appropriate radiotracer, both diseased healthy tissues measured Among applications cancer cognitive studies. advantageous exploited, however, at substantially high cost, which mainly because necessity include cyclotron part center involve radiochemists radiopharmacists physicists work same team addition clinicians.