Cerebrospinal fluid antibodies to coronavirus in patients with Parkinson's disease.

摘要: The etiology of Parkinson's disease remains unknown, and a search for environmental agents continues. In 1985, Fishman induced infection the basal ganglia by coronavirus in mice. Although is recognized primarily as respiratory pathogen humans, its affinity led us to investigate possible role human disease. cerebrospinal fluid normal controls (CTL) (n = 18), patients with (PD 20) other neurological (OND) 29) was analyzed blinded manner enzyme-linked immunosorbent assay [measurements optical density (OD) units] antibody response four antigens: mouse hepatitis virus JHM (J) A59 (A), 229E (E) OC43 (O). When compared CTL, PD had an elevated (p less than 0.05) mean OD J (0.0856 vs. 0.0207) A (0.1722 0.0636). Response greater O (0.0839 0.0071) that E (0.1261 0.0743). OND, 0.0267, p 0.05). Responses 0.0929) 0.0446) were 0.0946). These results suggest there may be association between PD.