The use of stem cells for pancreatic regeneration in diabetes mellitus

摘要: The endocrine pancreas represents an interesting arena for regenerative medicine and cell therapeutics. One of the major pancreatic diseases, diabetes mellitus is a metabolic disorder caused by having insufficient number insulin-producing β cells. Replenishment cells transplantation can restore normal control. shortage in donor pancreata has meant that demand transplantable outstripped supply, which could be met using alternative sources stem This situation opened up new areas research, such as cellular reprogramming vivo β-cell regeneration. Pluripotent seem to best option clinical applications regeneration near future, these have been demonstrated represent unlimited source functional Although compelling evidence shows adult retains capacity, it remains unclear whether this organ contains Alternatively, specialized types within or outside retain plasticity proliferation differentiation. Cellular transdifferentiation exocrine other provide long-term solution.