Synthesis method of 3,5-dimethyl-4-nitropyridine-N-oxide

摘要: The invention discloses a synthesis method of 3,5-dimethyl-4-nitropyridine-N-oxide, and belongs to the field chemical industry. comprises following steps: mixing 3,5-dimethyl pyridine-N-oxide with concentrated sulfuric acid so as form mixed liquid, dropwise adding solution potassium nitrate liquid at 0-60 DEG C, reacting 60-120 C for 0.5-12hr obtain 3,5-dimethyl-4-nitropyridine-N-oxide. by replacing nitric or fuming nitrating reagent, can be used greatly shortening reaction time avoiding generation brown smoke during post-processing, an operating environment is friendly, problem environmental pollution caused massive use relieved; meanwhile, yield improved well; since issue increasingly emphasized nowadays, 3,5-dimethyl-4-nitropyridine-N-oxide better reagent complete reaction.