Maternal Dyslipidemia, Plasma Branched-Chain Amino Acids, and the Risk of Child Autism Spectrum Disorder: Evidence of Sex Difference.
作者： Anita A. Panjwani , Yuelong Ji , Jed W. Fahey , Amanda Palmer , Guoying Wang
DOI: 10.1007/S10803-019-04264-X
关键词:
摘要: In contrast to the well-observed associations between obesity, diabetes, and autism spectrum disorder (ASD), roles of maternal dyslipidemia sex disparity in ASD have not been well-studied. We examined joint plasma cholesterols, branched-chain amino acids (BCAAs) child on risk. analyzed data from 756 mother-infant pairs (86 ASD) Boston Birth Cohort. Maternal cholesterols BCAAs were measured samples collected 24-72 h postpartum. found that this urban, low-income prospective birth cohort, low high-density lipoprotein cholesterol (HDL-C), above-median BCAA concentrations, male additively or synergistically increased risk ASD. Additional studies are necessary confirm our findings.
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