Cocaine can generate a stronger conditioned reinforcer than food despite being a weaker primary reinforcer
作者： Brendan J. Tunstall , David N. Kearns
DOI: 10.1111/ADB.12195
关键词:
摘要: The present study aimed to test the hypothesis that cues associated with drug-taking behavior become extra strong motivators of compared paired non-drug reinforcers. In experiment 1, rats were trained lever press for intravenous cocaine infusions and grain pellets. Each reinforcer was a distinct audiovisual cue. When allowed choose between these alternatives, chose on ~70-80 percent trials. However, after extinguishing pressing, reintroduction press-contingent during cue-induced reinstatement generated more seeking than (also observed 3- 8-week follow-up tests). To examine whether same pattern results would occur two reinforcers, 2 replicated 1 using sucrose as reinforcement alternatives. Rats over choice trials also responded cue test. disconnect primary conditioned reinforcements in but not suggests drug may exceptionally seeking. These are consistent cue-focused theories addiction offer insight into persistent cue-driven drug-seeking addiction.
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