The Inhibiting Effect of Dinitrosyl Iron Complexes with Thiol-containing Ligands on the Growth of Endometrioid Tumours in Rats with Experimental Endometriosis
作者： Evgeniya N. Burgovа , Yana I. Khristidis , Aleksandr V. Kurkov , Vasak D. Mikoyan , Anatoly B. Shekhter
DOI: 10.1007/S12013-019-00865-6
关键词:
摘要: The possibility that binuclear dinitrosyl iron complexes with glutathione and cysteine (DNIC-GSН B-DNIC-Cys) have a strong cytotoxic effect on the growth of endometrioid tumours (EMT) in rats surgically induced experimental endometriosis established our previous studies has been supported data. increase DNIC-GSН or B-DNIC-Cys dose from 10 (in studies) to 20 μmol/kg (after i/p administration rats) fully suppressed uterine tissues implanted onto inner surface abdominal wall. At 2 μmol/kg DNIC-GSН, median value EMT volume increased 0 15 mm3, while mean size EMT—from 55 77 mm3 (data measurements rats). After treatment animals B-DNIC N-acetyl-L-cysteine (10 μmol/kg) known for its ability penetrate easily through cell membrane, inhibiting diminished as could be evidenced transformation ~30% implants into large-size EMT. Possible reasons this phenomenon are discussed.
springer.com
sci-hub.se 参考文章(21)
H. Sasaki, T. Maruyama, H. Sato, N. Kataoka, H. Nakada, S. Nagase, Identification of three-line electron spin resonance signal and its relationship to ascites tumors. Cancer Research. ,vol. 31, pp. 179- 184 ,(1971)
Anatoly F. Vanin, Dinitrosyl Iron Complexes with Natural Thiol-Containing Ligands: Physicochemistry, Biology, and Medicine Bioorganometallic Chemistry. pp. 203- 238 ,(2014) , 10.1002/9783527673438.CH07
Rostislav R. Borodulin, Lyudmila N. Kubrina, Vasak D. Mikoyan, Alexander P. Poltorakov, Vyacheslav О. Shvydkiy, Dosymzhan Sh. Burbaev, Vladimir A. Serezhenkov, Elena R. Yakhontova, Anatoly F. Vanin, Dinitrosyl iron complexes with glutathione as NO and NO⁺ donors. Nitric Oxide. ,vol. 29, pp. 4- 16 ,(2013) , 10.1016/J.NIOX.2012.11.001
Evgeny I. Chazov, Oleg V. Rodnenkov, Andrey V. Zorin, Vladimir L. Lakomkin, Vladimir V. Gramovich, Oleg N. Vyborov, Anatoly G. Dragnev, Аlexander А. Timoshin, Lyudmila I. Buryachkovskaya, Alexander A. Abramov, Valery P. Massenko, Evgeny V. Arzamastsev, Valery I. Kapelko, Anatoly F. Vanin, Hypotensive effect of Oxacom® containing a dinitrosyl iron complex with glutathione: animal studies and clinical trials on healthy volunteers. Nitric Oxide. ,vol. 26, pp. 148- 156 ,(2012) , 10.1016/J.NIOX.2012.01.008
Leila V. Adamyan, Vasak D. Mikoyan, Oksana V. Paklina, Asiya A. Stepanyan, Anatoly F. Vanin, Evgeniya N. Burgova, Nikolai А. Tkachev, Dinitrosyl iron complexes with glutathione suppress experimental endometriosis in rats. European Journal of Pharmacology. ,vol. 727, pp. 140- 147 ,(2014) , 10.1016/J.EJPHAR.2014.01.002
S. V. Yurtaeva, V. N. Efimov, N. I. Silkin, A. A. Rodionov, M. V. Burmistrov, A. V. Panov, A. A. Moroshek, Magnetic Resonance of Ferritin Crystalline Particles in Tumor Tissue Applied Magnetic Resonance. ,vol. 42, pp. 299- 311 ,(2012) , 10.1007/S00723-012-0312-2
Anatoly F. Vanin, Vladimir A. Serezhenkov, Vasak D. Mikoyan, Michael V. Genkin, The 2.03 Signal as an Indicator of Dinitrosyl–Iron Complexes with Thiol-Containing Ligands☆ Nitric Oxide. ,vol. 2, pp. 224- 234 ,(1998) , 10.1006/NIOX.1998.0180
Anatoly F. Vanin, Dinitrosyl iron complexes with thiolate ligands: Physico-chemistry, biochemistry and physiology Nitric Oxide. ,vol. 21, pp. 1- 13 ,(2009) , 10.1016/J.NIOX.2009.03.005
Andrei L. Kleschyov, Susanne Strand, Steffen Schmitt, Daniela Gottfried, Michael Skatchkov, Nikolajs Sjakste, Andreas Daiber, Victor Umansky, Thomas Munzel, Dinitrosyl-iron triggers apoptosis in Jurkat cells despite overexpression of Bcl-2 Free Radical Biology and Medicine. ,vol. 40, pp. 1340- 1348 ,(2006) , 10.1016/J.FREERADBIOMED.2005.12.001
N. M. EMANUEL, A. N. SAPRIN, V. A. SHABALKIN, L. E. KOZLOVA, K. E. KRUGLJAKOVA, Detection and Investigation of a New Type of ESR Signal characteristic of Some Tumour Tissues Nature. ,vol. 222, pp. 165- 167 ,(1969) , 10.1038/222165A0