Ictogenesis: the origin of seizures in humans. A new look at an old theory.

摘要: Seizure (ictal) behavior in humans has been observed and recorded since ancient times. A satisfactory solution to this vexing problem continues elude medical science. Antiepileptic drug (AED) therapy fails control seizures 20% of patients with primary generalized epilepsy 35% partial many side effects, including death. This paper cites evidence from the current literature that supports a plausible hypothesis seizure genesis was published 1942, but somehow escaped recognition. It presents concept challenges contemporary thinking may provide basis for much needed paradigm shift understanding nature an approach their management. The theory views as natural reflex defense response lethal threat brain. Although capable inflicting bodily injury due falls, drowning, etc., is not considered inherently harmful brain be associated beneficial circulatory changes. Efforts prevent should directed away pharma-chemical suppression towards developing methods bioactive agents promote neuroplasticity, neurogenesis, optimized physiological milieu within