Altitude, exercise and immune function.

摘要: Little is known with regard to how acute and chronic high altitude exposure effects immune function. Hypoxia an environmental stressor that elicit alterations in both the autonomic nervous system endocrine Alterations these systems can have immediate as well a longer lasting impact on Studies from summit of Pikes Peak (4300 m) indicated strong alpha- & beta-adrenergic component regulation function at persist weeks after initial exposure. Specifically, interleukin (IL)-6 elevated primarily mediated via stimulation remains for several result alpha-adrenergic activation. When added stress physical exercise combined hypoxia, more pronounced observed compared either or hypoxia alone. A popular training paradigm currently employed by endurance athletes enhance performance involves living while low altitude. The concept entails incorporating physiologic metabolic adaptations associated (increase RBC, mitochondrial oxidative capacity, capillary density, etc) lower allowing maintenance absolute intensity. Others demonstrated short-term application (18 days) live high-train results suppression mucosal cumulative decline salivary IgA levels. Taken together, majority evidence suggests potential additive effect transiently suppressing function, least short-term. Implications are addressed.