Endotoxin in the environment – exposure and effects

摘要: This review deals with endotoxin in the environment and its relation to disease among exposed persons. Data are presented on levels of different environments maximum values several microg/m(3). The cellular reactions importance for inhalation exposure effects attachment lipopolysaccharide binding protein, CD14 cell surface protein TLR-4 receptors. internalisation macrophages endothelial cells results local production inflammatory cytokines subsequent migration into lung penetration blood. These events orchestrate clinical terms toxic pneumonitis, airways' inflammation systemic symptoms. Inhalation challenges pure field studies confirm between these dusts containing endotoxin. It is possible that polymorphism genes determining reactivity, particularly TLR-4, influences risk after environmental exposures. Some data suggest caused by inhaled may decrease atopic sensitisation children cancer workers organic dust. Additional research needed clarify role other agents present connection endotoxin, (1-->3)-beta-D-glucan from mold walls.