DNA-catalyzed polymerization.
作者： Xiaoyu Li , Zheng-Yun J. Zhan , Rachel Knipe , David G. Lynn
DOI: 10.1021/JA017319J
关键词:
摘要: Native DNA oligomers are shown to be stereoselective catalysts for the polymerization of 5‘-amino-3‘-acetaldehyde-modified thymidine/adenosine nucleosides through reductive amination. The reaction follows step-growth kinetics read encoded sequence and chain-length information in antiparallel direction. Single mismatches template selected against at a level >100:1. A method is therefore established translate biopolymer-encoded stereoselectively into sequence- specific synthetic polymers.
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