T cell Response to Carbamylated and Citrullinated Collagen Epitopes in HLA-DRβ1*04-Positive Patients With Rheumatoid Arthritis: Comment on the Article by Anderson et al.

J. Backlund, S. Carlsen, T. Hoger, B. Holm, L. Fugger, J. Kihlberg, H. Burkhardt, R. Holmdahl, Predominant selection of T cells specific for the glycosylated collagen type II epitope (263–270) in humanized transgenic mice and in rheumatoid arthritis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 9960- 9965 ,(2002) , 10.1073/PNAS.132254199

Abdallah Badou, Magali Savignac, Marc Moreau, Catherine Leclerc, Gilles Foucras, George Cassar, Pierre Paulet, Dominique Lagrange, Philippe Druet, Jean-Charles Guéry, Lucette Pelletier, Weak TCR stimulation induces a calcium signal that triggers IL‐4 synthesis, stronger TCR stimulation induces MAP kinases that control IFN‐γ production European Journal of Immunology. ,vol. 31, pp. 2487- 2496 ,(2001) , 10.1002/1521-4141(200108)31:8<2487::AID-IMMU2487>3.0.CO;2-L

Piotr Mydel, Zeneng Wang, Mikael Brisslert, Annelie Hellvard, Leif E. Dahlberg, Stanley L. Hazen, Maria Bokarewa, Carbamylation-Dependent Activation of T Cells: A Novel Mechanism in the Pathogenesis of Autoimmune Arthritis Journal of Immunology. ,vol. 184, pp. 6882- 6890 ,(2010) , 10.4049/JIMMUNOL.1000075

Maria Cristina De Rosa, Bruno Giardina, Caterina Bianchi, Cristiana Carelli Alinovi, Davide Pirolli, Gianfranco Ferraccioli, Maria De Santis, Gabriele Di Sante, Francesco Ria, Modeling the Ternary Complex TCR-Vβ/CollagenII(261–273)/HLA-DR4 Associated with Rheumatoid Arthritis PLOS ONE. ,vol. 5, pp. 1- 11 ,(2010) , 10.1371/JOURNAL.PONE.0011550

Francesco Ria, Romina Penitente, Maria De Santis, Chiara Nicolò, Gabriele Di Sante, Massimiliano Orsini, Dario Arzani, Andrea Fattorossi, Alessandra Battaglia, Gian Ferraccioli, Collagen-specific T-cell repertoire in blood and synovial fluid varies with disease activity in early rheumatoid arthritis Arthritis Research & Therapy. ,vol. 10, pp. 1- 18 ,(2008) , 10.1186/AR2553

Kirsten M. Anderson, Christina L. Roark, Mary Portas, Michael T. Aubrey, Edward F. Rosloniec, Brian M. Freed, A Molecular Analysis of the Shared Epitope Hypothesis: Binding of Arthritogenic Peptides to DRB1*04 Alleles Arthritis & Rheumatology. ,vol. 68, pp. 1627- 1636 ,(2016) , 10.1002/ART.39636