Bleeding risks associated with inheritance of the Quebec platelet disorder.

摘要: Quebec platelet disorder (QPD) is an autosomal dominant bleeding associated with increased urokinase-type plasminogen activator in platelets and alpha-granule protein degradation. To determine risks common manifestations of QPD, a history questionnaire was developed administered to 127 relatives family QPD. Data entry done blinded affected unaffected status, determined by assays for (u-PA) fibrinogen Odds ratios (ORs), 95% confidence intervals (CIs), were items queried. Summative scores each individual calculated using OR more than 1. Mean ages (34 years; range, 1-89 years) similar (n = 23) 104) members. Affected individuals had higher mean (P 20) having that led lifestyle changes, bruises spread lower or as large larger orange both, joint bleeds, longer 24 hours after dental extractions deep cuts, received been recommended other treatments (fibrinolytic inhibitors) bleeding. Individuals QPD exposure(s) hemostatic challenges experienced excessive only when fibrinolytic inhibitors not used. These data illustrate can be modified inhibitors.