Review article: the role of rapid virological response in determining treatment duration for chronic hepatitis C

摘要: Aliment Pharmacol Ther 31, 1251–1267 Summary Background  For patients with chronic hepatitis C, attaining rapid virological response (RVR) is highly predictive of SVR. Aim  To consider the value RVR in terms SVR and relapse. Methods  Data were collected from published clinical trials to define for evaluate proposed continuum linking relapse. Results  These data support a 24-week regimen among genotype (G)1 who attain positive values (PPVs) 77.8% 85.7% G1 infection treated 24 48 weeks. Conversely, failure should not be viewed as criterion extending treatment duration beyond 48 weeks: negative (NPVs) 60.9% 52.7% without 48 72 weeks. Among G2/3 patients, has high PPV; however, NPV varied indicating that warranted fail RVR. Conclusions  The present analysis confirms strong predictor can used tailor duration, but which also appreciated context regimen.