Three-year cardiovascular events and disease progress in patients with peripheral arterial disease: results from the Japan Medication Therapy for Peripheral Arterial Disease (J-METHOD).

摘要: AIM To investigate the current status of peripheral arterial disease (PAD) drug treatment in Japan, and effects treatment, risk factors, complications on progress onset cardiovascular events PAD patients. METHODS In this prospective observational cohort study, 557 patients were followed up for 3 years, monitored. RESULTS Three drugs, i.e., beraprost sodium, cilostazol, aspirin, most frequently used. The who had undergone vascular reconstruction lower limbs before enrollment showed significant improvement ABI. Among not enrollment, there was a ABI after with beraprost. During observation period, deaths occurred 35 (6.3%), heart diseases 63 (11.3%), brain 39 (7.0%), 94 (16.9%). factors affecting increase explored by multivariate analysis (Cox regression analysis). As result, age (75 years or older), ischemic severity Fontaine classification identified as deaths, whereas kidney disorders diseases, number oral drugs treating (younger than 75 years), dialysis, (less 0.7) aspirin limbs. CONCLUSION result three-year follow-up Japanese cohort, could be identified.