Adiposity and weight gain during pregnancy associate independently with behavior of infant rhesus monkeys (Macaca mulatta).

摘要: Growing evidence identifies maternal adiposity as a potentially modifiable risk factor for adverse neurodevelopment. This retrospective cohort analysis examined whether prepregnancy and gestational weight gain were associated with behavioral outcomes in 173 rhesus macaque infants at the California National Primate Research Center. Dams conceived indoors, had uncomplicated pregnancies, delivered vaginally, reared indoors. Infants underwent standardized biobehavioral 90-120 days of age from 3/2001-5/2015. Offspring mothers greater baseline or exhibited pattern poor adaptability characterized by emotionality assessments proceeded, blunted affective response to human intruder challenge, reduced interest novel stimuli which is poorer social functioning later life. They also lower cortisol levels following dexamethasone suppression, perhaps excess during gestation. These results amplify growing public health concerns implicating impaired fetal neurobehavioral programming.