Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors

作者: Marton Siklos , Manel BenAissa , Gregory R.J. Thatcher

DOI: 10.1016/J.APSB.2015.08.001

关键词:

摘要: Cysteine proteases continue to provide validated targets for treatment of human diseases. In neurodegenerative disorders, multiple cysteine proteases provide targets for enzyme …

参考文章(213)
Supriti Samantaray, Swapan Ray, Naren Banik, Calpain as a Potential Therapeutic Target in Parkinsons Disease Cns & Neurological Disorders-drug Targets. ,vol. 7, pp. 305- 312 ,(2008) , 10.2174/187152708784936680
Mala V Rao, Panaiyur S Mohan, Corrinne M Peterhoff, Dun-Sheng Yang, Stephen D Schmidt, Philip H Stavrides, Jabbar Campbell, Yuanxin Chen, Ying Jiang, Peter A Paskevich, Anne M Cataldo, Vahram Haroutunian, Ralph A Nixon, Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression The Journal of Neuroscience. ,vol. 28, pp. 12241- 12254 ,(2008) , 10.1523/JNEUROSCI.4119-08.2008
Syu-ichi Hirai, Hiroshi Kawasaki, Moshe Yaniv, Koichi Suzuki, Degradation of transcription factors, c-Jun and c-Fos, by calpain. FEBS Letters. ,vol. 287, pp. 57- 61 ,(1991) , 10.1016/0014-5793(91)80015-U
Bruce E. Maryanoff, Michael J. Costanzo, Inhibitors of proteases and amide hydrolases that employ an α-ketoheterocycle as a key enabling functionality Bioorganic & Medicinal Chemistry. ,vol. 16, pp. 1562- 1595 ,(2008) , 10.1016/J.BMC.2007.11.015
S. Taniguchi, Y. Fujita, S. Hayashi, A. Kakita, H. Takahashi, S. Murayama, T.C. Saido, S. Hisanaga, T. Iwatsubo, M. Hasegawa, Calpain‐mediated degradation of p35 to p25 in postmortem human and rat brains FEBS Letters. ,vol. 489, pp. 46- 50 ,(2001) , 10.1016/S0014-5793(00)02431-5
Toshimasa Tsujinaka, Yuki Kajiwara, Junichi Kambayashi, Masato Sakon, Naoki Higuchi, Takaharu Tanaka, Takesada Mori, Synthesis of a new cell penetrating calpain inhibitor (calpeptin) Biochemical and Biophysical Research Communications. ,vol. 153, pp. 1201- 1208 ,(1988) , 10.1016/S0006-291X(88)81355-X
Yong Zhang, Seo Yoon Jung, Changbae Jin, Nam Doo Kim, Ping Gong, Yong Sup Lee, Design and synthesis of 4-aryl-4-oxobutanoic acid amides as calpain inhibitors. Bioorganic & Medicinal Chemistry Letters. ,vol. 19, pp. 502- 507 ,(2009) , 10.1016/J.BMCL.2008.11.030
Rumi Ishisaka, Toshihiko Utsumi, Munehisa Yabuki, Tomoko Kanno, Takashi Furuno, Masayasu Inoue, Kozo Utsumi, Activation of caspase-3-like protease by digitonin-treated lysosomes FEBS Letters. ,vol. 435, pp. 233- 236 ,(1998) , 10.1016/S0014-5793(98)01080-1