Hematologic and immunologic effects of the systemic administration of recombinant interleukin-2 after autologous bone marrow transplantation
作者： D Blaise , D Olive , AM Stoppa , P Viens , C Pourreau
DOI: 10.1182/BLOOD.V76.6.1092.1092
关键词:
摘要: T cells from allogeneic bone marrow grafts are responsible for a graft versus leukemia effect. Use of recombinant Interleukin-2 (rIL-2) after autologous transplantation (BMT) may enhance immune function and hopefully reproduce the reaction. We report here hematologic immunologic changes observed in first 10 patients phase 1 trial studying infusion IL-2 BMT. All had high-risk malignancies received 6 days constant (Eurocetus, Amsterdam, The Netherlands) at dose 3 x 10(6) Cetus Units/m2/d, 79 +/- 12 Clinical toxicities involving cutaneous, cholestatic, gastrointestinal, hemodynamic effects occurred during treatment but reversed all cases. Completion was 91% scheduled IL-2. Hematologic toxicity moderate transient with no failure. Increases eosinophil lymphocyte counts were significant (P less than .05). Stimulation system intense prolonged, manifested by increase numbers CD3+, CD3+DR+, CD3+ CD25+ lymphocytes, natural killer (NK) (all P .01), Lymphokine-activated killers (LAK) NK activities .01 This study establishes feasibility 6-day administration rIL-2 BMT leading to major activation 2.5 months
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sci-hub.se 参考文章(13)
D. Maraninchi, B. Mascret, J. L. Lagrange, J. P. Guillet, J. A. Gastaut, G. Sebahoun, H. Perrimond, J. Camerlo, Y. Carcassonne, Evaluation of Cyclophosphamide and Different TBI Regimens (Single Dose or Fractionnated) in Allogeneic Marrow Transplantation for Hematologic Malignancies Springer Berlin Heidelberg. pp. 33- 33 ,(1985) , 10.1007/978-3-662-40457-7_20
RobertPeter Gale, RichardE. Champlin, HOW DOES BONE-MARROW TRANSPLANTATION CURE LEUKAEMIA? The Lancet. ,vol. 324, pp. 28- 30 ,(1984) , 10.1016/S0140-6736(84)92009-9
M. H. Gaspard, D. Maraninchi, A. M. Stoppa, J. A. Gastaut, G. Michel, N. Tubiana, D. Blaise, G. Novakovitch, J. F. Rossi, P. J. Weiller, D. Sainty, N. Horchowski, Y. Carcassonne, Intensive chemotherapy with high doses of BCNU, etoposide, cytosine arabinoside, and melphalan (BEAM) followed by autologous bone marrow transplantation: toxicity and antitumor activity in 26 patients with poor-risk malignancies. Cancer Chemotherapy and Pharmacology. ,vol. 22, pp. 256- 262 ,(1988) , 10.1007/BF00273421
JOËLLE HIRN-SCAVENNEC, HERVÉ BRAILLY, DOMINIQUE MARANINCHI, PATRICE MANNONI, CLAUDE MAWAS, MICHEL DELAAGE, Elimination of leukemia cells from human bone marrow using floating beads. Transplantation. ,vol. 46, pp. 558- 562 ,(1988) , 10.1097/00007890-198810000-00018
Rainer Storb, E. Donnall Thomas, Allogeneic Bone‐Marrow Transplantation Immunological Reviews. ,vol. 71, pp. 77- 102 ,(1983) , 10.1111/J.1600-065X.1983.TB01069.X
Fefer A, Cox T, Lindgren Cg, Thompson Ja, Higuchi Cm, Buckner Cd, Lymphokine-activated Killer Function following Autologous Bone Marrow Transplantation for Refractory Hematological Malignancies Cancer Research. ,vol. 49, pp. 5509- 5513 ,(1989)
S L Schwarz, S A Rosenberg, J J Mulé, P J Spiess, C M Reichert, Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2. Journal of Experimental Medicine. ,vol. 161, pp. 1169- 1188 ,(1985) , 10.1084/JEM.161.5.1169
M A Cheever, P D Greenberg, A Fefer, S Gillis, Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2. Journal of Experimental Medicine. ,vol. 155, pp. 968- 980 ,(1982) , 10.1084/JEM.155.4.968
J. Reiffers, M. H. Gaspard, D. Maraninchi, M. Michallet, G. Marit, A. M. Stoppa, B. Corront, B. David, J. A. Gastaut, J. J. Sotto, A. Broustet, Y. Carcassonne, D. HOLLARD, Comparison of allogeneic or autologous bone marrow transplantation and chemotherapy in patients with acute myeloid leukaemia in first remission: a prospective controlled trial. British Journal of Haematology. ,vol. 72, pp. 57- 63 ,(1989) , 10.1111/J.1365-2141.1989.TB07652.X
Alexander Fefer, Current status of syngeneic marrow transplantation and its relevance to autografting Clinics in Haematology. ,vol. 15, pp. 49- 65 ,(1986) , 10.1016/S0308-2261(86)80005-4