Adaptogenic potential of Oxitard in experimental chronic stress and chronic unpredictable stress induced dysfunctional homeostasis in rodents.

摘要: Abstract Background Oxitard, a polyherbal formulation comprising the extracts of Withania somnifera , Mangifera indica Glycyrrhiza glabra Daucus carota Vitis vinifera powders Syzygium aromaticum Yashada bhasma and Emblica officinalis ; oils Triticum sativum . Objective Current study deals with assessment Oxitard (a marketed formulation) for its adaptogenic potential in chronic unpredictable stress (CUS) (CS) induced dysfunctional homeostasis rodents. Materials & methods Animals were immobilized 2 h every day ten days to induce CS. In order CUS, animals employed battery stressors variable value duration days. Following administration was animals. Stress-induced efficient changes evaluated by assessing organ (adrenal gland) weights, ulcer index, hematological parameters biochemical levels reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) catalase (CAT). Results CS CUS significantly modified oxidative (increased MDA decreased GSH). Furthermore, lead weight reduction, adrenal hypertrophy gastric ulceration. Pre-treatment (200 400 mg/kg, p.o.) changes, pathological effects. Conclusion conclusion, Oxitard-intervened antioxidant actions are accountable effects stress-induced homeostasis.