Structural disorder and its role in proteasomal degradation

摘要: The ubiquitin proteasome system is responsible for the controlled degradation of a vast number intracellular proteins. It targets misfolded or otherwise aberrant proteins as well no longer needed at given point in time. 26S large macromolecular machine comprising 33 distinct subunits transiently associating cofactors. Being essentially non-specific protease, specificity conferred by system, which selects and marks substrates degradation. Here, we review our current understanding structure function proteasome; doing so highlight role disordered protein regions. Disordered segments promote their degradation, whereas low complexity regions prevent proteolysis. In itself main seems to be rendering receptors mobile, possibly supporting recruitment polyubiquitylated substrates. Thus, these structural features likely play important roles different stages process.