Determination of Liothyronine and Levothyroxine in Thyroid Preparations by Liquid Chromatography

作者: Steven L. Richheimer , Charlotte B. Jensen

DOI: 10.1002/JPS.2600750225

关键词:

摘要: Liothyronine and levothyroxine were quantitatively determined in samples of commercial thyroid tablets bulk powders. Samples first hydrolyzed using a bacterial protease then analyzed by high-performance liquid chromatography. Various hydrolysis conditions investigated. The liothyronine contents powders found to be ˜8–11 μg 25–43 μg, respectively, per 65 mg thyroid. stability the iodothyronines was also

参考文章(9)
W. F. Devlin, N. R. Stephenson, The chemical determination of liothyronine and thyroxine in enzymic hydrolysates of pork thyroid. Journal of Pharmacy and Pharmacology. ,vol. 14, pp. 597- 604 ,(2011) , 10.1111/J.2042-7158.1962.TB11144.X
Robert W. Rees-Jones, P.Reed Larsen, Triiodothyronine and thyroxine content of desiccated thyroid tablets Metabolism-clinical and Experimental. ,vol. 26, pp. 1213- 1218 ,(1977) , 10.1016/0026-0495(77)90113-5
ROBERT A. HATCHER, THE UNITED STATES PHARMACOPEIA. Journal of the American Medical Association. ,vol. L, pp. 30- 34 ,(1908) , 10.1001/JAMA.1908.25310270030002F
Joseph E. Moody, John R. Hohmann, Gilbert B. Kaplan, Chemical Determination of the Potency of Thyroid Preparations Journal of Pharmaceutical Sciences. ,vol. 57, pp. 634- 639 ,(1968) , 10.1002/JPS.2600570419
VINCENT J. PILEGGI, ORVILLE J. GOLUB, NORMAN D. LEE, DETERMINATION OF THYROXINE AND TRIIODOTHYRONINE IN COMMERCIAL PREPARATIONS OF DESICCATED THYROID AND THYROID EXTRACT. The Journal of Clinical Endocrinology and Metabolism. ,vol. 25, pp. 949- 956 ,(1965) , 10.1210/JCEM-25-7-949
Roman Bilous, John J. Windheuser, Determination of Liothyronine and Thyroxine in Dried Thyroid by GLC Journal of Pharmaceutical Sciences. ,vol. 62, pp. 274- 277 ,(1973) , 10.1002/JPS.2600620220
R. LEMIEUX, J. M. TALMAGE, The determination of liothyronine and thyroxine in thyroid preparations. Journal of Pharmacy and Pharmacology. ,vol. 18, pp. 94- 100 ,(2011) , 10.1111/J.2042-7158.1966.TB07830.X
SELAHATTIN KOLOGLU, HAROLD L. SCHWARTZ, ANNE C. CARTER, Quantitative determination of the thyroxine, triiodothyronine, monoiodotyrosine and diiodotyrosine content of desiccated thyroid. Endocrinology. ,vol. 78, pp. 231- 239 ,(1966) , 10.1210/ENDO-78-2-231
Steven L. Richheimerx, Merl S. Schachet, Rapid and Simplified Assay for Thyroid in Pharmaceutical Preparations by Potentiometric Titration Journal of Pharmaceutical Sciences. ,vol. 72, pp. 822- 823 ,(1983) , 10.1002/JPS.2600720728