Binding and aggregation mechanism of amyloid β-peptides onto the GM1 ganglioside-containing lipid membrane.

摘要: Accumulation and fibril formation of amyloid β (Aβ) peptides onto a ganglioside-rich lipid membrane is cause neuro-disturbance diseases. To find out measure for suppressing the nucleation seed fibrils, mechanism initial binding Aβ to should be clarified. Molecular dynamics simulations were carried investigate adhesion process GM1-ganglioside-containing membrane. Multiple computational trials executed analyze probability occurrence by using calculation models containing mixed membrane, water layer, one, two, or three Aβs. The demonstrated that approached after fluctuation in layer occasionally made steady contact with Once had been established, was unlikely detached from developed into more stably bound form. In form, neuraminic acids on GM1 cluster str...