Functional consequences of immune cell adhesion to endothelial cells.

摘要: Research regarding the interactions between endothelium and immune cells has undergone a significant expansion during past decade. Major shifts of emphasis have been norm, from production detail catalog cell surface receptors counter-receptors acting at interface vascular circulating to more mechanistic account leukocyte/endothelium interactions. The five years seen new, groundbreaking developments in field, with exiting studies aimed understanding functional consequences direct contact endothelial leukocytes. Based on early work be discussed below, new data local chemokine cell-to-cell contacts, attempt clarify physiopathological significance these events. exceptional anatomical arrangement insures permanent leukocytes, an event likely result cellular signals originating or through action soluble factors produced by cells. As we will discuss, current evidence supports idea that present as well specialized high venules, play not only critical role homing recruitment but it can also influence outcome response. Additionally, clearly corroborates B T lymphocytes NK modulate function.