Lack of interferon-γ receptor results in a microenvironment favorable for intestinal tumorigenesis.

摘要: IFN-γ plays an important role in innate and adaptive immunity. signaling is also involved tumorigenesis, with both pro- antitumor activities documented. We here report the characterization of intestinal tumorigenesis ApcMin/+ mice that lack receptor. observed Ifngr1-/-ApcMin/+ are shorter-lived than Ifngr1+/+ApcMin/+ mice. The tumors more likely to progress into invasive adenocarcinomas. Gene expression profiling by RNA sequencing revealed a significant upregulation genes inflammation tissue remodeling when compared those In particular, five encoding matrix metallopeptidases (MMPs) were among upregulated. On other hand, promote or maintain differentiation, such as Cdx2, Cdhr2 Cdhr5, downregulated. Tumor-associated macrophages abundant favored toward M2 polarization Furthermore, Ifngr1 was significantly downregulated mucosa. A similar trend noted for human colorectal carcinomas. Together, our results indicate adequate critical maintaining tumor-prohibitive microenvironment.