Synaptic vesicle protein 2: A multi-faceted regulator of secretion.

作者: Kristine Ciruelas , Daniele Marcotulli , Sandra M. Bajjalieh

DOI: 10.1016/J.SEMCDB.2019.02.003

关键词:

摘要: Synaptic Vesicle Protein 2 (SV2) comprises a recently evolved family of proteins unique to secretory vesicles that undergo calcium-regulated exocytosis. In this review we consider SV2s' structural features, evolution, and function discuss its therapeutic potential as the receptors for an expanding class drugs used treat epilepsy cognitive decline.

参考文章(136)
Anna L. Meehan, Xiaofeng Yang, Li-Lian Yuan, Steven M. Rothman, Levetiracetam has an activity-dependent effect on inhibitory transmission Epilepsia. ,vol. 53, pp. 469- 476 ,(2012) , 10.1111/J.1528-1167.2011.03392.X
Vamsee S. Reddy, Maksim A. Shlykov, Rostislav Castillo, Eric I. Sun, Milton H. Saier, The major facilitator superfamily (MFS) revisited FEBS Journal. ,vol. 279, pp. 2022- 2035 ,(2012) , 10.1111/J.1742-4658.2012.08588.X
E. A. Matveeva, S. W. Whiteheart, J. T. Slevin, Accumulation of 7S SNARE complexes in hippocampal synaptosomes from chronically kindled rats. Journal of Neurochemistry. ,vol. 84, pp. 621- 624 ,(2003) , 10.1046/J.1471-4159.2003.01589.X
B A Davletov, T C Südhof, A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. Journal of Biological Chemistry. ,vol. 268, pp. 26386- 26390 ,(1993) , 10.1016/S0021-9258(19)74326-9
Roger Janz, Kay Hofmann, Thomas C. Südhof, SVOP, an Evolutionarily Conserved Synaptic Vesicle Protein, Suggests Novel Transport Functions of Synaptic Vesicles The Journal of Neuroscience. ,vol. 18, pp. 9269- 9281 ,(1998) , 10.1523/JNEUROSCI.18-22-09269.1998
Jessie Gu, Berkley A Lynch, Dina Anderson, Henrik Klitgaard, Sun Lu, Michael Elashoff, Ulrich Ebert, Heidrun Potschka, Wolfgang Löscher, None, The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of rats. European Journal of Neuroscience. ,vol. 19, pp. 334- 345 ,(2004) , 10.1111/J.0953-816X.2003.03106.X
Xiaofeng Yang, Joseph Bognar, Tianyu He, Mouhari Mohammed, Isabelle Niespodziany, Christian Wolff, Manuel Esguerra, Steven M. Rothman, Janet M. Dubinsky, Brivaracetam augments short-term depression and slows vesicle recycling Epilepsia. ,vol. 56, pp. 1899- 1909 ,(2015) , 10.1111/EPI.13223
Anthony Carruthers, Amy L. Helgerson, The human erythrocyte sugar transporter is also a nucleotide binding protein. Biochemistry. ,vol. 28, pp. 8337- 8346 ,(1989) , 10.1021/BI00447A011
K. Sawada, N. Echigo, N. Juge, T. Miyaji, M. Otsuka, H. Omote, A. Yamamoto, Y. Moriyama, Identification of a vesicular nucleotide transporter. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 5683- 5686 ,(2008) , 10.1073/PNAS.0800141105