Anti-apoptotic activity of low levels of wild-type p53

摘要: Induction of apoptosis is a function both an external stimulus and the physiology cell, which includes expression multiple oncogenes tumor suppressors. Here we have studied apoptotic response immortalized mouse fibroblasts to serum withdrawal. We show that, in addition p53-independent observed p53- cells, overexpression wild-type p53 suppressor results high rate programmed cell death. However, physiological range, low levels protein protect from induction apoptosis. Our indicate as its dose, can either death or promote This new, anti-apoptotic, activity may implications for understanding role played by embryonic development well initial stages oncogenesis.